Mutagenicity tests on propiverine hydrochloride.
نویسندگان
چکیده
منابع مشابه
Propiverine hydrochloride immediate and extended release: comparison of efficacy and tolerability in patients with overactive bladder.
INTRODUCTION This study aims to compare the efficacy of propiverine hydrochloride immediate release (IR), propiverine hydrochloride extended release (ER) and placebo for the treatment of overactive bladder syndrome. The primary outcome measure is incontinence episode frequency, with secondary outcome measures including mean volume per void and quality of life as assessed on King's Health Questi...
متن کاملTaste masking of propiverine hydrochloride by conversion to its free base.
The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourier transform infrared spectroscopy, thermogravimetry-differential thermal analysis, and powder X-ray diffraction spectra, we confirmed that P-4 had ...
متن کاملthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولEffects of propiverine and its metabolite propiverine-N-oxide on bladder contraction and salivation in mini pigs.
PURPOSE The objective of this study was to evaluate the influence of propiverine-HCl (P4) and propiverine-N-oxide (P4NO), one of the major metabolites of P4, on bladder contraction in a standardized in vivo model. Additionally, salivary flow measurements enabled the evaluation of hyposalivation, one of the most predominant anticholinergic side effects. MATERIALS AND METHODS Ten male mini pigs...
متن کاملon Frameshift Mutagenicity
Some derivatives ot' 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding aMnity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding aMnity, whjle {he introdu ¢ tion of chlorine increased them. Halogenated derivatSyes f 1 showed higher toxicity against Saintonella mphiinu...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1989
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.14.131